Clinical Sarcoma Research

1. A clinico-genomic analysis of soft tissue sarcoma patients reveals CDKN2A deletion as a biomarker for poor prognosis

   Sarcomas are a rare, heterogeneous group of tumors with variable tendencies for aggressive behavior. Molecular markers for prognosis are needed to risk stratify patients and identify those who might benefit fr...

2. The challenge of sarcomas: the patient advocacy group perspective

   The patient advocacy agenda covers every aspect of cancer treatment and care. This inevitably means that this review covers almost everything that patient advocates are involved with, whether locally, national...

3. A rare presentation of carcinosarcoma of the bone in a young female; response with gemcitabine and docetaxel

   Sarcomatoid carcinoma, or carcinosarcoma, is a neoplasm that contains both sarcomatous and carcinomatous elements. It is an extremely rare cancer most often arising from visceral organs. Here we report the sev...

4. Radiotherapy resistance in chondrosarcoma cells; a possible correlation with alterations in cell cycle related genes

   Conventional chondrosarcomas are malignant cartilage tumors considered radioresistant. Nevertheless, retrospective series show a small but significant survival benefit for patients with locally advanced diseas...

5. Immunophenotypic expression of UCP1 in hibernoma and other adipose/non adipose soft tissue tumours

   Uncoupling protein 1 (UCP1) is a mitochondral protein transporter that uncouples electron transport from ATP production. UCP1 is highly expressed in brown adipose tissue (BAT), including hibernomas, but its ex...